Housed in a complex of papal palaces, the Palazzi Papali, this museum showcases a fine collection of religious relics from the Duomo and paintings by artists such as Arnolfo di Cambio and the three Pisanos (Andrea, Nino and Giovanni). A separate exhibition in Palazzo Soliano is dedicated to sculptor and medallist Emilio Greco (1913–95).

　　The ticket also covers admission to the ex-Chiesa di Sant'Agostino (Piazza San Giovenale) where the museum's sculptural collection is on show.